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Trembolone Profile
Trenbolone Profile
The drug trenbolone is undoubtedly the most powerful injectable anabolic steroid that already exists. However, its properties are not fully understood. This profile will separate fact from fiction and help them decide if trenbolone is for you or not.
Trenbolone is very similar to the popular steroid nandrolone, since both are 19-nor steroids, meaning that a testosterone molecule has been altered at the 19th position to give us a new compound. Unlike nandrolone however trenbolone is an excellent drug for lean mass gains, with the majority of gains being muscle fiber, with minimal water retention (1). It has an unbelievable anabolic (muscle building) score of 500. Compared to testosterone, which in itself is a powerful muscle builder and has a score of 100, you can begin to understand the potential of trenbolone muscle building. What makes trenbolone so anabolic? Many factors come into play. Trenbolone increases the level of the hormone IGF-1 in muscle tissue (2). And, it is noted in addition to double the levels of IGF-1 in muscle also makes satellite cells (cells that repair damaged muscle) are more sensitive to IGF-1 and other growth factors (3). The amount of DNA per muscle cell may also be significantly increased (3).
Trenbolone also has a very strong affinity to the androgen receptor (AR), binding much more strongly than testosterone (4). This is important because the stronger a steroid binds to the androgen receptor, the better it works by activating the mechanisms of HR for muscle growth. There is also strong evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss.Think of the receptors as locks and androgens as different keys, where some keys open the locks better and more easily than others. This does not mean that the affinity to the AR is the final word on the efficacy of a steroid. Anadrol The character has no measurable binding to the androgen receptor ... And we all know how potent Anadrol is to build muscle.
Trenbolone increases nitrogen retention in muscle tissue (5). The nitrogen retention is a strong indicator of how anabolic a substance is. However, the amazing muscle building effects of trenbolone does not end there. Trenbolone has the ability to bind to the receptors of the anti-anabolic hormones glucocorticoids (6). This can also have the effect of inhibiting the catabolic hormone cortisol (7).
Another amazing trait of trenbolone should be noted is its ability to improve feed efficiency and mineral absorption in animals (8). To help you understand what this means, feed efficiency is a measure of the amount of meat that an animal in a diet can produce. The more food is needed to produce the same amount of meat, lower the efficiency. Conversely, the less food to produce the same amount of meat, the higher the efficiency ... In animals given trenbolone gained high quality weight without having their diet adjusted, thus improving feed efficiency. Finding new compounds which can improve feed efficiency is a billion dollar industry, and has spawned many nutritional advances in bodybuilding over the last decades (CLA, Whey Protein, and HMB are compounds which spring to mind as having been first introduced in the livestock industry. What this means for the athlete who trains hard? The food you eat will be better utilized for building lean muscle, and vitamins and minerals are also better absorbed which may keep you healthier during cycle.
Trenbolone is also a highly androgenic hormone, when compared with testosterone, which has a ratio of 100; Trenbolone has an astonishing 500. Highly androgenic steroids are appreciated for the effects they have on strength as well as changing the estrogen / androgen, thus reducing water retention under the skin. As the report on trenbolone was not good enough, it gets better; Trenbolone is an extraordinary agent for fat loss. One reason for this is its powerful effect on nutrient partitioning (9). It is a little known fact that androgen receptors are found in both fat cells and muscle cells (10). Androgens act directly on the AR in fat cells to affect fat burning (11). The stronger the androgen binds to the AR, is the most lipolytic effect on adipose tissue (11). Since some steroids even increase the numbers of AR in muscle and fat (11, 12), this fat loss effect would be amplified with the concurrent use of other compounds such as testosterone.
Trenbolone promotes the production of red blood cells and increases the rate of glycogen replenishment, significantly improving recovery (13). Like almost all steroids, the effects of this drug are dose dependent, with higher dosages having the greatest impact on body composition and strength. Mood changes are a notorious side effect of trenbolone (15), androgens increase chemicals in the brain that promote aggressive behavior (16), which can be beneficial for some athletes wanting to improve speed and power.
The chemical structure of trenbolone makes it resistant to the enzyme aromatase (which converts to estrogen) thus absolutely no percentage of trenbolone will convert to estrogen. The administration of trenbolone will not promote estrogen-related side effects such as breast tissue growth in men (gynecomastia) fat gain and water retention. Trenbolone is also resistant to 5alfa-reductase enzyme. This enzyme reduces some steroid hormones into a more androgenic form. In the case of trenbolone, however, does not matter. Trenbolone boasts an androgenic ratio of 500, which can easily cause adverse side effects in anyone prone to hair loss, prostate enlargement, oily skin and acne. Unfortunately, the possible side effects do not end there. Trenbolone is also a progestin: it binds to the receptor of the female sex hormone progesterone (with about 60% strength progesterone) (17). In predisposed users, this can lead to bloat and breast growth worse, active Trenbolone (17beta-trenbolone) has an affinity for the progesterone receptor (PGR), which is actually greater than progesterone itself (18).
However, there is no need to panic, antiestrogenic or letrozole may reduce the levels of progesterone and combat any progestenic. The use of a 19-nor compound like trenbolone also increases prolactin ... Bromocriptine or cabergoline are often recommended to maintain these lower levels (20).Testicular atrophy (shrunken balls) may also occur; HCG used intermittently throughout a cycle can prevent this (21). It is also wise for Tren users to closely monitor their cholesterol levels, as well as kidney and liver function, because the "train" has the potential to negatively affect all these functions. Trenbolone, being a powerful progestin, will also shut down natural testosterone production, even a relatively small dose of testosterone suppresses the production for an extended period of time. This can cause low libido and erectile dysfunction. It is essential that you always stack trenbolone with a good dose of testosterone.
The acetate ester is a very short chain ester attached to the trenbolone molecule.It has an active life of 2-3 days, but to keep blood levels of trenbolone elevated and steady, daily injections are often recommended. Acetate provides a rapid and high concentration of hormones, which is beneficial for those seeking quick gains, coupled with a rapid end of the side effects when discontinued its use.
Now that the properties of trenbolone acetate have been explained we can better understand how to use it in order to maximize its advantages. Evidence suggests that trenbolone when used with estrogen promotes more weight gain that trenbolone alone (22), now I'm not telling you to go take some birth control trenbolone but the addition of flavoring oral such as Dianabol and a long ester testosterone such as cypionate or enanthate would produce great gains in a cycle of mass gain. For a cutting cycle trenbolone is the best choice you have, the powerful effect on nutrient shuttling allows a user to restrict calories and remain in a state of positive nitrogen balance (remember what that means?). The cortisol reducing effect and binding to the glucocorticoid receptor will greatly reduce the catabolic effects of harsh dieting and excessive amounts of cardio ... Not to mention that trenbolone itself fat burning (due to its strong connection to the AR. A good choice for a setting loop to "train" is Stanozolol. He has a low affinity to the AR and thus will act in your body in vastly different ways than the Tren. Moreover, Stanozolol is a DHT-based drug and Tren is a 19-nor ... with a short-lived testosterone (propionate) you will have a cutting cycle which takes advantage of all three main families of anabolic steroids (testosterone, 19-nor, and DHT), as well as different affinities with AIR (binding affinities and mechanisms of action). Ironically, despite the "train" to be an excellent pre-contest drug, it lowers your levels of thyroid hormones (23), and this raises prolactin. I recommend taking T3 (25mcg / day) along with trenbolone in order to avoid elevating your prolactin.
In addition, this drug is a poor choice for athletes who rely on cardiovascular fitness to play. Apparently at least, it reduces the ability of athletes to maintain high levels of resistance. Unfortunately, this makes Tren a poor choice for many.
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