Profile Methenolone

Time of action: 4-6 hours (oral acetate), 4-5 days (acetate injectable) 10-14 days (enanthate)
Reported Dosage: 50-300mg per day (oral) 200-700mg per week (injection)
Aromatize: no
Converted into DHT, no
Acne: Yes
Water Retention: no
High Blood Pressure: no
Inhibits the HPT axis: yes, little
Hepatotoxic, no
The Effects

Methenolone is a drug derived from DHT (or more precisely the dihydroboldenone DHB, resulting from the reduction of boldenone in contact with the enzyme 5-alpha reductase), and like any drug derived from an already reduced EAA, it does not become estrogen. In fact, Methenolone has been successfully used in treatment of breast cancer (5), and considering that these treatments are usually made by anti-estrogens, we can say (at least theoretically) that Methenolone has anti-estrogenic, explaining why many users feel less water retention, gynecomastia, and tendency to accumulate fat located Methenolone if they involve any other drugs that have estrogenic activity. Despite having low androgenic value (somewhere between 44 and 55), Methenolone binds to androgen receptors more strongly than testosterone itself (1), making it an excellent fat burner. In addition, methenolone acts positively on the retention of nitrogen (2), it being one of the few drugs able to keep your anabolic potential even in periods of caloric restriction (6). Add those three features and have an excellent drug for setting cycles.

The increase in nitrogen balance promoted by Methenolone is also conducive to building muscle. Two studies conducted with sheep, concluded that animals that received Methenolone developed more muscle mass when compared to animals that were not submitted to the administration of this drug (3) (4). Unfortunately there are no studies on the anabolic potential of methenolone in humans, however, results in sheep confirm the reports of countless users who have used or use of AAS in their cycles, so that the probability of the results of studies with sheep have repeat when applied to humans is great. Another interesting fact is that the sheep subjected to the administration of Methenolone developed more strength than their counterparts who remained "pure." I must say that the phenomenon is repeated in humans?

The muscle mass built during the use of methenolone usually of excellent quality.Without the presence of estrogen and water retention, the muscles become more defined as they become larger and more apparent. However, Methenolone is not exactly the best drug as it comes to building muscle. Although it has an anabolic considerable value (88% of testosterone in vitro), Methenolone is not a drug for larger gains in muscle mass, but for those seeking moderate results and good quality. Like any drug that exhibits these characteristics, the results achieved with methenolone usually easily maintained post-cycle (6).
The esters

In general, Methenolone is found in the form of two different prodrugs: Methenolone enanthate or acetate Methenolone. Although not as common as Methenolone enanthate, this drug in their acetate version has some nice features, at least interesting. Although the Methenolone acetate can be administered by injection, it is one of the few drugs that are not 17-alpha alkylated and that can be administered orally, all without losing its effectiveness. Its alkylation at carbon 1 and carbon 17 beta esterification make Methenolone is transformed into an active metabolite after passing through the liver allowing it to enter the bloodstream and exert their effects, although much of the administered dose is deactivated this process. Simply put, Methenolone acetate can be administered orally without causing harm to the liver (except in large doses) (6). However, because a higher dose necessary to achieve the same effectiveness, the oral administration of Methenolone acetate is more costly than injectable administration. When we speak of oral administration of Methenolone acetate, although the dose range for this drug has been designed over time, there are no studies or even a consensus on the amount of drug that enters the bloodstream, causing the a specific dosage adjustment is almost a "long shot". The only reference on this point comes from Bill Roberts, based on empirical knowledge that says that "oral administration may have only half as potent as injectable administration" (7).

The differences in action for Methenolone enanthate and acetate esters are very small, since the Methenolone not convert to estrogen and does not undergo changes due to the 5a-reductase. Thus, one should not expect much difference in the results (or even the side) between an ester and another. However we must remember that the enanthate ester is heavier than the acetate ester, so that in the same amount of pro-drug (or acetate Methenolone enanthate) has been more free in their version Methenolone acetate enanthate than his version. To illustrate the table, about 70mg Methenolone be released into the bloodstream for each 100mg Methenolone enanthate administered, while approximately 85mg of methenolone are released for each 100mg Methenolone acetate administered.Obviously, here we are considering the administration by injection, since the reasons given above any comparison of injectable versus oral genre would most likely fail.

Over time, the idea that the acetate Methenolone promotes greater fat burning that Methenolone enanthate. According to proponents of this current, the acetate ester is responsible for increasing the effect of methenolone fat burner. Although this idea was dated today, either for lack of scientific support or lack of logic, this concept became popular back in the past and is still in some sites and forums around the globe, so it is necessary reinforce the lack of support of this statement in order that the reader not to confuse future when faced with this concept, which is actually more of a number of myths present in this medium.
The Use

During the oral administration of acetate Methenolone, the lack of alkylation at carbon 17 makes the half-life becomes very low, hovering around 2-3 hours.Therefore, to avoid gaps in the action of the drug, it is preferable that the administration of methenolone is made quite often, as little as one administration every 2 hours, trying to keep the levels in the bloodstream Methenolone the most stable possible. The lack of alkylation is also required administration of a high daily dose, since a considerable part of the drug will be disabled during the first passage through the liver. Although the lowest effective dose is 50 mg per day (value found in many references), I believe it is very difficult even for a novice user to obtain satisfactory results with less than 80-100mg per day. Whereas Methenolone itself is a mild drug and that without the 17-alpha-alkylated oral bioavailability Methenolone acetate is compromised, it is not hard to understand why 50mg per day is not enough to promote good results.

The injectable version of the acetate Methenolone possess half-life of about 2 days. Thus, it is necessary that the drug is administered every two days (one day in, day out). Methenolone enanthate already possess half-life between 5 and 7 days, making the administration of this drug is much more comfortable because you will need fewer applications. Despite the possibility of administering the Methenolone enanthate once every 5 days (or even just once a week), most users choose to administer it twice a week. As is usually the Methenolone enanthate does not cause pain beyond that generated by the drilling of the needle, administering this drug (as many others) two times a week is hardly a nuisance.With the administration of injectable Methenolone regardless of the ester, the drug reaches the bloodstream without major losses. Although it is a soft drug, about 200-250mg per week are sufficient to promote satisfactory results in a novice user and without a history of AAS. However, more advanced users may need larger doses to about 300-500mg per week to achieve the expected result.

In the cycles of definition, with the focus on fat loss, drugs such as oxandrolone, trenbolone drostonolona and may be associated with methenolone to enhance the results. With proper control of estrogen, testosterone propionate and boldenone are also good options. For cycles in which one seeks to increase muscle mass without compromising quality, you can combine Methenolone with drugs that do not aromatize (or has a low rate of aromatization) as stanozolol, Turinabol, testosterone propionate, boldenone and nandrolone phenylpropionate.In the great cycles that aim to increase muscle volume, Methenolone is not usually used since it does not promote drastic results of weight, strength or volume.
The Side

Side by side with oxandrolone, methenolone dispute the top of the list of safer drugs with fewer side effects. Thanks to the lower cost of acquisition and higher oral bioavailability, oxandrolone is far more popular than methenolone today, although the two drugs are roughly equivalent in terms of security. Why not show many side effects and results by providing solid and easy to maintain, created the theory that methenolone causes very little suppression of the HPT axis. However, a study using dosages of Methenolone acetate (oral) between 30mg and 45mg per day showed a reduction in the production of LH / FSH between 15% and 65% (8). Knowing that, in general, you need a higher dose than that used in this study to achieve satisfactory results, the logic can be expected also by the suppression of the HPT axis even greater. However, EAA is a mild and do not convert to estrogen, the suppression caused by Methenolone not quite so great when compared to other drugs like testosterone or methandrostenolone trenbolone.This same property (little or no suppression of the HPT axis) was attributed to oxandrolone, and was also overturned by subsequent studies.

As we do not convert to estrogen, side effects such as gynecomastia, water retention and high blood pressure are not a problem during the use of methenolone. As stated previously, methenolone appears to have anti-estrogenic properties, which help to combat this type of collateral, and not the other. Though it lacks a lot of potential androgen, side effects such as hair loss, acne, oily skin and hair growth by the body are possible, albeit mild.

So far I have not found studies on the effects of methenolone on cholesterol.However, those users who underwent testing after cycles containing Methenolone reported only slight changes in the values ​​of HDL and LDL, indicating that it may act Methenolone lenient on these indicators.

References
1. Endocrinology. 1984 Jun; 114 (6) :2100-6.
2. Wien Med Wochenschr. 1993; 143 (14-15) :368-75
3. Ann Thorac Surg 1995; 59:961-969
4. European Journal of Cardio-Thoracic Surgery, Vol 8, 214-219
5. Med Klin. 1981 Nov 20; 76 (24) :689-91
6. L Rea, Chemical Muscle Enhancement, 2002
7. Bill Roberts, https://www.mesomorph.../primobolan.htm
8. Arzneimittelforshung. 1970 20 (4) 545-7